IMPHFREF TRIAL: STUDY PROTOCOL FOR AN OPEN-LABEL, MULTICENTRE STUDY OF IMPROVEMENT THE OUTCOME OF PATIENTS WITH HEART FAILURE IN CHINA USING A MOBILE HEALTH-SUPPORTED PLATFORM

Background Patients with chronic heart failure (CHF) often have a long duration of illness, difficulty in attending follow-up visits, and poor adherence to treatment.As a result, they frequently cannot receive guideline-directed medical therapy (GDMT) at the desired or maximum tolerable drug dosage.This leads to high hospitalisation and mortality r

Abstract Antibody derivatives have sought to recapitulate the antigen binding properties of antibodies, but with improved biophysical attributes convenient for therapeutic, diagnostic and research applications.However, their success has been limited by the naturally occurring structure of the immunoglobulin dimer displaying hypervariable binding lo

Introduction: The implementation of futile nursing interventions seems to be a persistent problem in adult intensive care units.Understanding this phenomenon can contribute to its prevention and all deleterious effects associated with it.Objective: To identify the perceptions utility fork of expert nurses from adult intensive care units about thera

Abstract Accurate identification of molecular alterations in gliomas is crucial for their diagnosis and treatment.Although, fluorescence in situ hybridization (FISH) allows for the observation of diverse and heterogeneous alterations, it is inherently time-consuming and challenging due to the limitations of the molecular method.Here, we report the